Effects of GGX on an Ovalbumin-induced Asthma Mice Model

Objective: The purpose of this study is to evaluate the effects GGX on an ovalbumin (OVA)-induced asthma mice model.Methods: Balb/c were challenged with OVA and then treated three concentrations (100, 200, 400 mg/kg). After sacrifice, bronchoalveolar lavage fluid (BALF) or lungs analyzed by fluorescence-activated cell sorting, ELISA, real-time PCR, H&E, Masson’s trichrome, PAS AB-PAS staining, immunohistofluorescence staining.Results: significantly inhibited increase total cells, immune cells (lymphocyte, neutrophils, macrophage, CD4+, CD8+, CD4+CD69+, CD62L-CD44high+, Gr-1+SiglecF-), expression cytokines (IL-4, IL-5, IL-13, IFN-γ) in BALF. It also eosinophil/macrophage, CD3+, CD19+, CD3+CD193+, TARC, MCP-1 lung tissue. decreased severity histological injury expressions STAT3 GATA3.Conclusion: This suggests probability using for treatment inhibiting inflammatory response.